HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure.
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ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC5485317 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure.
Yang Runkuan R Zou Xiaoping X Tenhunen Jyrki J Tønnessen Tor Inge TI
Mediators of inflammation 20170613
Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear. Emerging evidence shows that ALF patients/animals have high concentrations of circulating HMGB1, which can contribute to multiple organ injuries and mediate gut bact ...[more]
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