Ontology highlight
ABSTRACT:
SUBMITTER: Sandberg R
PROVIDER: S-EPMC548538 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Sandberg Rickard R Ernberg Ingemar I
Proceedings of the National Academy of Sciences of the United States of America 20050125 6
The gene expression profiles of 60 cell lines, derived from nine different tissues, were compared with their corresponding in vivo tumors and tissues. Cell lines expressed few tissue-specific (2%) or tumor-specific (5%) genes when analyzed group-wise. A tissue similarity index (TSI) was designed based upon singular value decomposition that measured in vivo tumor characteristic gene expression in each cell line independently. Only 34 of the 60 cell lines received the highest TSI toward its tumor ...[more]