Ontology highlight
ABSTRACT:
SUBMITTER: Kalkat M
PROVIDER: S-EPMC5485515 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kalkat Manpreet M De Melo Jason J Hickman Katherine Ashley KA Lourenco Corey C Redel Cornelia C Resetca Diana D Tamachi Aaliya A Tu William B WB Penn Linda Z LZ
Genes 20170525 6
MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulation often leads to constitutive overexpression of MYC, which can be achieved through gross genetic abnormaliti ...[more]