Ontology highlight
ABSTRACT:
SUBMITTER: Sonoda J
PROVIDER: S-EPMC548561 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Sonoda Junichiro J Chong Ling Wa LW Downes Michael M Barish Grant D GD Coulter Sally S Liddle Christopher C Lee Chih-Hao CH Evans Ronald M RM
Proceedings of the National Academy of Sciences of the United States of America 20050125 6
Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular disease. We report here that loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator of enterohepatic drug metabolism and clearance, results in an unexpected acute lethality associated with signs of severe hepatorenal failure when mice are fed with a diet that elicits accumulation of ...[more]