Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC5485635 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhu Ying Y Zhang Longhui L Zha Haoran H Yang Fei F Hu Chunyan C Chen Lin L Guo Bo B Zhu Bo B
International journal of biological sciences 20170601 6
Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen super family, is a pleiotropic cytokine that impacts diverse cellular functions. Previous studies have shown that tumor cell-derived Fgl2 promotes tumorigenesis and metastasis in immune-deficient mice, and it also functions as an immune-suppressive modulator in glioblastoma multiform (GMB). This study aimed to evaluate whether and how tumor stroma-derived Fgl2 affects tumorigenesis and tumor progression. We established the syngeneic tr ...[more]