Ontology highlight
ABSTRACT:
SUBMITTER: Sharan R
PROVIDER: S-EPMC548573 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Sharan Roded R Suthram Silpa S Kelley Ryan M RM Kuhn Tanja T McCuine Scott S Uetz Peter P Sittler Taylor T Karp Richard M RM Ideker Trey T
Proceedings of the National Academy of Sciences of the United States of America 20050201 6
To elucidate cellular machinery on a global scale, we performed a multiple comparison of the recently available protein-protein interaction networks of Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae. This comparison integrated protein interaction and sequence information to reveal 71 network regions that were conserved across all three species and many exclusive to the metazoans. We used this conservation, and found statistically significant support for 4,645 previ ...[more]