Ontology highlight
ABSTRACT:
SUBMITTER: Keirns J
PROVIDER: S-EPMC5485736 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20170213 6
The effects of isavuconazole (active moiety of isavuconazonium sulfate) on cardiac ion channels in vitro and cardiac repolarization clinically were assessed in a phase I, randomized, double-blind study in healthy individuals who received isavuconazole (after 2-day loading dose), at therapeutic or supratherapeutic doses daily for 11 days, moxifloxacin (400 mg q.d.), or placebo. A post-hoc analysis of the phase III SECURE trial assessed effects on cardiac safety. L-type Ca<sup>2+</sup> channels we ...[more]