Dataset Information

Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation.

ABSTRACT: BACKGROUND:Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging. METHODS:Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods. Nine programs provided data on head circumference and conditions potentially contributing to microcephaly. RESULTS:The pooled prevalence of microcephaly was 8.7 per 10,000 live births. Median prevalence (per 10,000 live births) was similar among programs using active (6.7) and passive (6.6) methods; the interdecile range of prevalence estimates was wider among programs using passive methods for all race/ethnicity categories except Hispanic. Prevalence (per 10,000 live births) was lowest among non-Hispanic Whites (6.5) and highest among non-Hispanic Blacks and Hispanics (11.2 and 11.9, respectively); estimates followed a U-shaped distribution by maternal age with the highest prevalence among mothers <20 years (11.5) and ?40 years (13.2). For gestational age and birth weight, the highest prevalence was among infants <32 weeks gestation and infants <1500 gm. Case definitions varied; 41.8% of cases had an HC ? the 10th percentile for sex and gestational age. CONCLUSION:Differences in methods, population distribution of maternal/infant characteristics, and case definitions for microcephaly can contribute to the wide range of observed prevalence estimates across individual birth defects surveillance programs. Addressing these factors in the setting of Zika virus infection can improve the quality of prevalence estimates. Birth Defects Research (Part A) 106:972-982, 2016. © 2016 Wiley Periodicals, Inc.

SUBMITTER: Cragan JD

PROVIDER: S-EPMC5485911 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation.

Cragan Janet D JD Isenburg Jennifer L JL Parker Samantha E SE Alverson C J CJ Meyer Robert E RE Stallings Erin B EB Kirby Russell S RS Lupo Philip J PJ Liu Jennifer S JS Seagroves Amanda A Ethen Mary K MK Cho Sook Ja SJ Evans MaryAnn M Liberman Rebecca F RF Fornoff Jane J Browne Marilyn L ML Rutkowski Rachel E RE Nance Amy E AE Anderka Marlene M Fox Deborah J DJ Steele Amy A Copeland Glenn G Romitti Paul A PA Mai Cara T CT

Birth defects research. Part A, Clinical and molecular teratology 20161101 11

<h4>Background</h4>Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging.<h4>Methods</h4>Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods. Nine progr ...[more]

PMID: 27891783

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Dataset Information

Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation.

Publications

Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation.

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