Ontology highlight
ABSTRACT:
SUBMITTER: Tsapogas P
PROVIDER: S-EPMC5485939 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Tsapogas Panagiotis P Mooney Ciaran James CJ Brown Geoffrey G Rolink Antonius A
International journal of molecular sciences 20170524 6
The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical prognosis. In the present review we provide an overview of our current knowledge on the rol ...[more]