Ontology highlight
ABSTRACT:
SUBMITTER: Frei C
PROVIDER: S-EPMC548645 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Frei Christian C Galloni Mireille M Hafen Ernst E Edgar Bruce A BA
The EMBO journal 20050203 3
The Drosophila melanogaster cyclin-dependent protein kinase complex CycD/Cdk4 stimulates both cell cycle progression and cell growth (accumulation of mass). CycD/Cdk4 promotes cell cycle progression via the well-characterized RBF/E2F pathway, but our understanding of how growth is stimulated is still limited. To identify growth regulatory targets of CycD/Cdk4, we performed a loss-of-function screen for modifiers of CycD/Cdk4-induced overgrowth of the Drosophila eye. One mutation that suppressed ...[more]