Ontology highlight
ABSTRACT:
SUBMITTER: Bates GJ
PROVIDER: S-EPMC548656 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Bates Gaynor J GJ Nicol Samantha M SM Wilson Brian J BJ Jacobs Anne-Marie F AM Bourdon Jean-Christophe JC Wardrop Julie J Gregory David J DJ Lane David P DP Perkins Neil D ND Fuller-Pace Frances V FV
The EMBO journal 20050120 3
The DEAD box RNA helicase, p68, has been implicated in various cellular processes and has been shown to possess transcriptional coactivator function. Here, we show that p68 potently synergises with the p53 tumour suppressor protein to stimulate transcription from p53-dependent promoters and that endogenous p68 and p53 co-immunoprecipitate from nuclear extracts. Strikingly, RNAi suppression of p68 inhibits p53 target gene expression in response to DNA damage, as well as p53-dependent apoptosis, b ...[more]