Estimates of linkage disequilibrium and effective population sizes in Chinese Merino (Xinjiang type) sheep by genome-wide SNPs.

ABSTRACT: Knowledge of linkage disequilibrium (LD) is important for effective genome-wide association studies and accurate genomic prediction. Chinese Merino (Xinjiang type) is well-known fine wool sheep breed. However, the extent of LD across the genome remains unexplored. In this study, we calculated autosomal LD based on genome-wide SNPs of 635 Chinese Merino (Xinjiang type) sheep by Illumina Ovine SNP50 BeadChip. A moderate level of LD (r² ≥ 0.25) across the whole genome was observed at short distances of 0-10 kb. Further, the ancestral effective population size (N_e ) was analyzed by extent of LD and found that N_e increased with the increase of generations and declined rapidly within the most recent 50 generations, which is cons

SUBMITTER: Liu S 

PROVIDER: S-EPMC5486679 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature