89Zr-Onartuzumab PET imaging of c-MET receptor dynamics.
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ABSTRACT:
SUBMITTER: Pool M
PROVIDER: S-EPMC5486818 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
<sup>89</sup>Zr-Onartuzumab PET imaging of c-MET receptor dynamics.
Pool Martin M Terwisscha van Scheltinga Anton G T AGT Kol Arjan A Giesen Danique D de Vries Elisabeth G E EGE Lub-de Hooge Marjolijn N MN
European journal of nuclear medicine and molecular imaging 20170319 8
<h4>Purpose</h4>c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug efficacy or emergence of resistance. Noninvasive visualization of c-MET dynamics could therefore potentially guide c-MET-directed therapies. We investigated the feasibility of <sup>89</sup>Zr-labelled one-armed c-MET antibody onartuzumab PET for detecting relevant changes in c-MET levels induced by c-MET-mediated epidermal growth ...[more]
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