Ontology highlight
ABSTRACT:
SUBMITTER: Seifert CW
PROVIDER: S-EPMC5486986 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Seifert Cole W CW Paniagua Armando A White Gabrielle A GA Cai Lucy L Li Guigen G
European journal of organic chemistry 20160308 9
A novel method for Fmoc/tBu solution-phase peptide synthesis and the development of a new benzyl-type GAP protecting group is reported. This new GAP protecting group is utilized in place of a polymer support, facilitating C→N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield, and was used to synthesize over 1 gram of the immunostimulant, thymopentin, in high overall yield (83%) and purity (99%). ...[more]