Identification, Bioactivity, and Productivity of Actinomycins from the Marine-Derived Streptomyces heliomycini.

ABSTRACT: In the process of profiling the secondary metabolites of actinobacteria isolated from the Saudi coastal habitats for production of antibiotics and anti-cancer drugs, the cultures of strain WH1 that was identified as Streptomyces heliomycini exhibited strong antibacterial activity against Staphylococcus aureus. By means of MS and NMR techniques, the active compounds were characterized as actinomycins X_0β, X₂, and D, respectively. The research on the productivity of this strain for actinomycins revealed that the highest production of actinomycins X_0β, X₂, and D was reached in the medium MII within 5% salinity and pH 8.5. In this optimized condition, the fermentation titers of actinomycins X_0β, X₂, and D were 107.

SUBMITTER: Wang D 

PROVIDER: S-EPMC5487404 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature