Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC5488038 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Yu Miao M Chen Liangkai L Peng Zhao Z Wang Di D Song Yadong Y Wang Hanying H Yao Ping P Yan Hong H Nüssler Andreas K AK Liu Liegang L Yang Wei W
Toxins 20170609 6
Deoxynivalenol (DON) belongs to the type B group of trichothecenes family, which is composed of sesquiterpenoid metabolites produced by Fusarium and other fungi in grain. DON may cause various toxicities, such as cytotoxicity, immunotoxicity, genotoxicity as well as teratogenicity and carcinogenicity. In the present study, we focus on a hypothesis that DON alters the expressions of Nrf2/HO-1 pathway by inducing embryotoxicity in C57BL/6 mouse (5.0, 2.5, 1.0, and 0 mg/kg/day) and BeWo cell lines ...[more]