Ontology highlight
ABSTRACT:
SUBMITTER: Hallow KM
PROVIDER: S-EPMC5488122 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hallow K M KM Gebremichael Y Y
CPT: pharmacometrics & systems pharmacology 20170526 6
Renal function plays a central role in cardiovascular, kidney, and multiple other diseases, and many existing and novel therapies act through renal mechanisms. Even with decades of accumulated knowledge of renal physiology, pathophysiology, and pharmacology, the dynamics of renal function remain difficult to understand and predict, often resulting in unexpected or counterintuitive therapy responses. Quantitative systems pharmacology modeling of renal function integrates this accumulated knowledg ...[more]