Exposure to phytoestrogens in utero and age at menarche in a contemporary British cohort.

ABSTRACT: Phytoestrogens are estrogenic compounds that occur naturally in plants. Phytoestrogens can cross the placenta, and animal studies have found associations between in utero exposure to phytoestrogens and markers of early puberty. We investigated the association between in utero exposure to phytoestrogens and early menarche (defined as <11.5 years of age at onset) using data from a nested case-control study within the Avon Longitudinal Study of Parents and Children, a longitudinal study involving families living in the South West of England. Concentrations of six phytoestrogens were measured in maternal urine samples collected during pregnancy. Logistic regression was used to explore associations between tertiles of phytoestrogen concentrations and menarche status, with adjustment for materna

SUBMITTER: Marks KJ 

PROVIDER: S-EPMC5488334 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature