Ontology highlight
ABSTRACT:
SUBMITTER: Dean ZS
PROVIDER: S-EPMC5488859 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Dean Zachary S ZS Elias Paul P Jamilpour Nima N Utzinger Urs U Wong Pak Kin PK
Analytical chemistry 20160816 17
Cancer is a leading cause of death worldwide and metastases are responsible for over 90% of human cancer deaths. There is an urgent need to develop novel therapeutics for suppressing cancer invasion, the initial step of metastasis. Nevertheless, the regulation of cancer invasion is poorly understood due to a paucity of tools for monitoring the invasion process in 3D microenvironments. Here, we report a double-stranded locked nucleic acid (dsLNA) biosensor for investigating 3D collective cancer i ...[more]