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Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe.

ABSTRACT: As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry concept was adopted. The model system presented here was developed for natural products with a terminal alkyne. Using our newly designed alkyne sensing beads with the aforementioned features, we have readily identified, quantified, and isolated compounds with a terminal alkyne group from plant extracts.

SUBMITTER: Jeon H

PROVIDER: S-EPMC5489024 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Chemical assay-guided natural product isolation <i>via</i> solid-supported chemodosimetric fluorescent probe.

Jeon Hongjun H Lim Chaemin C Lee Ji Min JM Kim Sanghee S

Chemical science 20150325 5

As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry concept was adopted. The model system presented here was developed for natural products with a terminal ...[more]

PMID: 28706669

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