Ontology highlight
ABSTRACT:
SUBMITTER: Yukimori A
PROVIDER: S-EPMC5489209 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Yukimori Akane A Oikawa Yu Y Morita Kei-Ichi KI Nguyen Chi Thi Kim CTK Harada Hiroyuki H Yamaguchi Satoshi S Kayamori Kou K Yamaguchi Akira A Ikeda Tohru T Sakamoto Kei K
PloS one 20170628 6
Calcifying cystic odontogenic tumors (CCOTs) are benign cystic tumors that form abnormally keratinized ghost cells. Mutations in CTNNB1, which encodes beta-catenin, have been implicated in the development of these tumors, but a causal relationship has not been definitively established. Thus, mutational hot spots in 50 cancer genes were examined by targeted next-generation sequencing in 11 samples of CCOT. Mutations in CTNNB1, but not in other genes, were observed in 10 of 11 cases. These mutatio ...[more]