Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer.
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ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC5489260 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer.
Kim Seonghoon S Jo HyeongChan H Jeon Mijeong M Choi Myung-Gyu MG Hahn Sei Kwang SK Yun Seok-Hyun SH
Chemical communications (Cambridge, England) 20170401 33
Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT. ...[more]
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