Ontology highlight
ABSTRACT:
SUBMITTER: Johanns M
PROVIDER: S-EPMC5489529 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Johanns Manuel M Lemoine Pascale P Janssens Virginie V Grieco Giuseppina G Moestrup Soren K SK Nielsen Rikke R Christensen Erik I EI Courtoy Pierre J PJ Emonard Hervé H Marbaix Etienne E Henriet Patrick P
Scientific reports 20170628 1
Matrix metalloproteinases (MMPs) are regulated at multiple transcriptional and post-transcriptional levels, among which receptor-mediated endocytic clearance. We previously showed that low-density lipoprotein receptor-related protein-1 (LRP-1) mediates the clearance of a complex between the zymogen form of MMP-2 (proMMP-2) and tissue inhibitor of metalloproteinases, TIMP-2, in HT1080 human fibrosarcoma cells. Here we show that, in BN16 rat yolk sac cells, proMMP-2:TIMP-2 complex is endocytosed t ...[more]