Ontology highlight
ABSTRACT:
SUBMITTER: Fan L
PROVIDER: S-EPMC5489557 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Fan Lu L Xiao Qingling Q Chen Yanyan Y Chen Gang G Duan Jinao J Tao Weiwei W
Frontiers in pharmacology 20170629
Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis. In the present study, we report that pekinenin E (PE), a casbane diterpenoid derived from the roots of <i>Euphorbia pekinensis</i>, has a strong antitumor activity against human HCC cells both <i>in vitro</i> and <i>in vivo</i>. PE suppressed the growth of human HCC cells Hep G2 and SMMC-7721. In addition, PE-mediated endoplasmic reticulum (ER) stress caused increasing expressions of C/EBP homologous protein ...[more]