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Fractional flow reserve: a clinical perspective.


ABSTRACT: Fractional flow reserve (FFR) is a reference invasive diagnostic test to assess the physiological significance of an epicardial coronary artery stenosis. FFR-guided percutaneous coronary intervention in stable coronary artery disease has been assessed in three seminal clinical trials and the indications for FFR assessment are expanding into other clinical scenarios. In this article we review the theoretical, experimental and clinical basis for FFR measurement. We place FFR measurement in the context of the comprehensive invasive assessment of coronary physiology in patients presenting with known or suspected angina pectoris in daily clinical practice, and review the recent developments in FFR assessment.

SUBMITTER: Corcoran D 

PROVIDER: S-EPMC5489582 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Fractional flow reserve: a clinical perspective.

Corcoran David D   Hennigan Barry B   Berry Colin C  

The international journal of cardiovascular imaging 20170602 7


Fractional flow reserve (FFR) is a reference invasive diagnostic test to assess the physiological significance of an epicardial coronary artery stenosis. FFR-guided percutaneous coronary intervention in stable coronary artery disease has been assessed in three seminal clinical trials and the indications for FFR assessment are expanding into other clinical scenarios. In this article we review the theoretical, experimental and clinical basis for FFR measurement. We place FFR measurement in the con  ...[more]

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