Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama S
PROVIDER: S-EPMC5489649 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yokoyama Seiya S Higashi Michiyo M Tsutsumida Hideaki H Wakimoto Jouji J Hamada Tomofumi T Wiest Edwin E Matsuo Kei K Kitazono Ikumi I Goto Yuko Y Guo Xin X Hamada Taiji T Yamada Sohsuke S Hiraki Tsubasa T Yonezawa Suguru S Batra Surinder K SK Hollingsworth Michael A MA Tanimoto Akihide A
Genes & cancer 20170301 3-4
Lung cancer remains a disease of high mortality, despite advanced diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion in lung neoplasms. Our immunohistochemistry (IHC) studies have shown that high MUC4 expression correlates with a poor outcome. We have also shown that the expression of several mucin genes in cancer cell lines is regulated by DNA methylation. We evaluated the expression level of MUC4, mRNA and several DNA hypomethylation factors in lung tis ...[more]