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Strong TCR?? Signaling Prohibits Thymic Development of IL-17A-Secreting ?? T Cells.

ABSTRACT: Despite a growing appreciation of ?? T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two distinct developmental pathways that generate ?? T cells pre-committed to subsequent secretion of either IL-17A or IFN?. Importantly, this framework for tracking ?? T cell development has permitted definitive assessment of TCR?? signal strength in commitment to ?? T cell effector fate; increased TCR?? signal strength profoundly prohibited the development of all IL-17A-secreting ?? T cells, regardless of V? usage, but promoted the development of ?? progenitors along the IFN? pathway. This clarifies the recently debated role of TCR?? signal strength in commitment to distinct ?? T cell effector fates and proposes an alternate methodology for the study of ?? T cell development.

SUBMITTER: Sumaria N

PROVIDER: S-EPMC5489697 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.

Sumaria Nital N Grandjean Capucine L CL Silva-Santos Bruno B Pennington Daniel J DJ

Cell reports 20170601 12

Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two distinct developmental pathways that generate γδ T cells pre-committed to subsequent secretion of either IL-17A or IFNγ. Importantly, this framework for tracking γδ T cell development has permitted definitive assessment of TCRγδ signal strength in commit ...[more]

PMID: 28636936

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