Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model.

ABSTRACT:

Background

Investigations in factor VII activating protease (FSAP)^-/- mice suggest a role for FSAP in stroke, thrombosis and neointima formation. Here, we analyzed the role of FSAP in vascular remodeling processes related to arteriogenesis and angiogenesis in the mouse hind limb ischemia model.

Methods and results

Femoral artery ligation was performed in mice and exogenous FSAP was injected locally to examine its effect on arteriogenesis in the adductor and angiogenesis in the gastrocnemius muscle over 21 days. Perfusion was decreased by FSAP, which was reflected in a lower arterial diameter and was associated with reduced monocyte infiltration in the adductor muscle. There was increased angiogenesis in the gastrocnemius muscle triggered indirectly by less blood s

SUBMITTER: Herold J 

PROVIDER: S-EPMC5489907 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature