Ontology highlight
ABSTRACT:
SUBMITTER: Xue Y
PROVIDER: S-EPMC5490002 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Xue Yali Y Mezzavilla Massimo M Haber Marc M McCarthy Shane S Chen Yuan Y Narasimhan Vagheesh V Gilly Arthur A Ayub Qasim Q Colonna Vincenza V Southam Lorraine L Finan Christopher C Massaia Andrea A Chheda Himanshu H Palta Priit P Ritchie Graham G Asimit Jennifer J Dedoussis George G Gasparini Paolo P Palotie Aarno A Ripatti Samuli S Soranzo Nicole N Toniolo Daniela D Wilson James F JF Durbin Richard R Tyler-Smith Chris C Zeggini Eleftheria E
Nature communications 20170623
The genetic features of isolated populations can boost power in complex-trait association studies, and an in-depth understanding of how their genetic variation has been shaped by their demographic history can help leverage these advantageous characteristics. Here, we perform a comprehensive investigation using 3,059 newly generated low-depth whole-genome sequences from eight European isolates and two matched general populations, together with published data from the 1000 Genomes Project and UK10 ...[more]