Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5490191 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhang Xiaowen X Chiang Huai-Chin HC Wang Yao Y Zhang Chi C Smith Sabrina S Zhao Xiayan X Nair Sreejith J SJ Michalek Joel J Jatoi Ismail I Lautner Meeghan M Oliver Boyce B Wang Howard H Petit Anna A Soler Teresa T Brunet Joan J Mateo Francesca F Angel Pujana Miguel M Poggi Elizabeth E Chaldekas Krysta K Isaacs Claudine C Peshkin Beth N BN Ochoa Oscar O Chedin Frederic F Theoharis Constantine C Sun Lu-Zhe LZ Curiel Tyler J TJ Elledge Richard R Jin Victor X VX Hu Yanfen Y Li Rong R
Nature communications 20170626
Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate BRCA1 in elimination of R-loops, DNA-RNA hybrid structures involved in transcription and genetic instability. Here we show that R-loops a ...[more]