Ontology highlight
ABSTRACT:
SUBMITTER: Purcell SM
PROVIDER: S-EPMC5490197 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Purcell S M SM Manoach D S DS Demanuele C C Cade B E BE Mariani S S Cox R R Panagiotaropoulou G G Saxena R R Pan J Q JQ Smoller J W JW Redline S S Stickgold R R
Nature communications 20170626
Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning, spindles may represent heritable biomarkers of neuropsychiatric disease. Here we characterize spindles in 11,630 individuals aged 4 to 97 years, as a prelude to future genetic studies. Spindle properties are highly reliable but exhibit distinct developmental trajectories. Across the night, we observe complex patterns of age- an ...[more]