Prevalence of sexual dimorphism in mammalian phenotypic traits.
Ontology highlight
ABSTRACT:
SUBMITTER: Karp NA
PROVIDER: S-EPMC5490203 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Prevalence of sexual dimorphism in mammalian phenotypic traits.
Karp Natasha A NA Mason Jeremy J Beaudet Arthur L AL Benjamini Yoav Y Bower Lynette L Braun Robert E RE Brown Steve D M SDM Chesler Elissa J EJ Dickinson Mary E ME Flenniken Ann M AM Fuchs Helmut H Angelis Martin Hrabe de MH Gao Xiang X Guo Shiying S Greenaway Simon S Heller Ruth R Herault Yann Y Justice Monica J MJ Kurbatova Natalja N Lelliott Christopher J CJ Lloyd K C Kent KCK Mallon Ann-Marie AM Mank Judith E JE Masuya Hiroshi H McKerlie Colin C Meehan Terrence F TF Mott Richard F RF Murray Stephen A SA Parkinson Helen H Ramirez-Solis Ramiro R Santos Luis L Seavitt John R JR Smedley Damian D Sorg Tania T Speak Anneliese O AO Steel Karen P KP Svenson Karen L KL Wakana Shigeharu S West David D Wells Sara S Westerberg Henrik H Yaacoby Shay S White Jacqueline K JK
Nature communications 20170626
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans. ...[more]
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