Dataset Information

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

ABSTRACT: Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.

SUBMITTER: Messa P

PROVIDER: S-EPMC5490529 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

Messa Piergiorgio P Regalia Anna A Alfieri Carlo Maria CM

Nutrients 20170527 6

Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged ...[more]

PMID: 28554998

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Project description:Reduction of cardiovascular death might have a significant effect on the long-term survival rates of renal transplant recipients (RTRs). The aim of the study was to assess the relation between arterial stiffness and graft function, adipose tissue content, and hydration status in patients after kidney transplantation (KTx).The study included 83 RTR patients (mean age: 55?±?13 years) who had been admitted to a nephrology-transplantation outpatient clinic 0.5 to 24 years after KTx. Clinical and laboratory data were analyzed and eGFR was calculated with the CKD-EPI formula. Arterial stiffness was assessed in all RTRs with pulse wave propagation velocity (PWV) with the use of a complior device. In addition, fluid and nutritional status was assessed with a Tanita BC 418 body composition analyzer. The control group consisted of 31 hospital workers who received no medication and had no history of cardiovascular disease.Multivariable linear regression analysis, with PWV as a dependent variable, retained the following independent predictors in the final regression model: red blood cell distribution width (RDW) (B?=?0.323; P?=?0.004), age (B?=?0.297; P?=?0.005), tacrolimus therapy (B?=?-0.286; P?=?0.004), and central DBP (B?=?0.185; P?=?0.041). Multivariable linear regression analysis with eGFR as a dependent variable retained the following independent predictors in the final regression model; creatinine concentration (B?=?-0.632; P?=?0.000), hemoglobin (B?=?0.280; P?=?0.000), CRP (B?=?-0.172; P?=?0.011), tacrolimus therapy (B?=?0.142; P?=?0.039), and triglycerides (B?=?-0.142; P?=?0.035).Our data indicates that: kidney transplant recipients can present modifiable CVD risk factors linked to increased arterial stiffness, DBP, waist circumference, SCr, time on dialysis, CyA therapy, and visceral fat mass; RDW is a parameter associated with arterial stiffness; and parameters such as CyA therapy, time on dialysis, PWV, RDW, and triglycerides show negative associations with the allograft function assessed with eGFR.

Dataset Information

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

Publications

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

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