Ontology highlight
ABSTRACT:
SUBMITTER: Waqas SFH
PROVIDER: S-EPMC5490745 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Waqas Syed F Hassnain SFH Hoang Anh Cuong AC Lin Ya-Tin YT Ampem Grace G Azegrouz Hind H Balogh Lajos L Thuróczy Julianna J Chen Jin-Chung JC Gerling Ivan C IC Nam Sorim S Lim Jong-Seok JS Martinez-Ibañez Juncal J Real José T JT Paschke Stephan S Quillet Raphaëlle R Ayachi Safia S Simonin Frédéric F Schneider E Marion EM Brinkman Jacqueline A JA Lamming Dudley W DW Seroogy Christine M CM Röszer Tamás T
The Journal of clinical investigation 20170605 7
The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese pati ...[more]