Ontology highlight
ABSTRACT:
SUBMITTER: Xia H
PROVIDER: S-EPMC5490771 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Xia Hong H Gilbertsen Adam A Herrera Jeremy J Racila Emilian E Smith Karen K Peterson Mark M Griffin Timothy T Benyumov Alexey A Yang Libang L Bitterman Peter B PB Henke Craig A CA
The Journal of clinical investigation 20170522 7
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a prevalence of 1 million persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli and leads to death by asphyxiation. We previously discovered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serve as a cell of origin for disease-mediating myofibroblasts. In a prior genomewide transcriptional analysis, we found that IPF MPCs displayed increased expression of S100 calcium-b ...[more]