Ontology highlight
ABSTRACT:
SUBMITTER: Morita K
PROVIDER: S-EPMC5490777 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Morita Ken K Suzuki Kensho K Maeda Shintaro S Matsuo Akihiko A Mitsuda Yoshihide Y Tokushige Chieko C Kashiwazaki Gengo G Taniguchi Junichi J Maeda Rina R Noura Mina M Hirata Masahiro M Kataoka Tatsuki T Yano Ayaka A Yamada Yoshimi Y Kiyose Hiroki H Tokumasu Mayu M Matsuo Hidemasa H Tanaka Sunao S Okuno Yasushi Y Muto Manabu M Naka Kazuhito K Ito Kosei K Kitamura Toshio T Kaneda Yasufumi Y Liu Paul P PP Bando Toshikazu T Adachi Souichi S Sugiyama Hiroshi H Kamikubo Yasuhiko Y
The Journal of clinical investigation 20170522 7
Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of evidence suggests that it has pro-oncogenic properties in acute myeloid leukemia (AML). Here we have demonstrated that the antileukemic effect mediated by RUNX1 depletion is highly dependent on a functional p53-mediated cell death pathway. Increased expression of other RUNX family members, including RUNX2 and RUNX3, compensated for the antitu ...[more]