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Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies.

ABSTRACT: Solid organ transplantation is a curative therapy for hundreds of thousands of patients with end-stage organ failure. However, long-term outcomes have not improved, and nearly half of transplant recipients will lose their allografts by 10 years after transplant. One of the major challenges facing clinical transplantation is antibody-mediated rejection (AMR) caused by anti-donor HLA antibodies. AMR is highly associated with graft loss, but unfortunately there are few efficacious therapies to prevent and reverse AMR. This Review describes the clinical and histological manifestations of AMR, and discusses the immunopathological mechanisms contributing to antibody-mediated allograft injury as well as current and emerging therapies.

SUBMITTER: Valenzuela NM

PROVIDER: S-EPMC5490786 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies.

Valenzuela Nicole M NM Reed Elaine F EF

The Journal of clinical investigation 20170612 7

Solid organ transplantation is a curative therapy for hundreds of thousands of patients with end-stage organ failure. However, long-term outcomes have not improved, and nearly half of transplant recipients will lose their allografts by 10 years after transplant. One of the major challenges facing clinical transplantation is antibody-mediated rejection (AMR) caused by anti-donor HLA antibodies. AMR is highly associated with graft loss, but unfortunately there are few efficacious therapies to prev ...[more]

PMID: 28604384

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