Ontology highlight
ABSTRACT:
SUBMITTER: Ryan LK
PROVIDER: S-EPMC5490828 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Ryan Lisa Kathleen LK Diamond Gill G
Viruses 20170621 6
While initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of expression of its gene, <i>DEFB1</i>, as well as activities that extend beyond direct antimicrobial. These observations suggest a complex role for hBD-1 in the host defense against viral infections, as evidenced by its expression in cells involved in viral defense, and its gene regulation in response to viral cha ...[more]