Ontology highlight
ABSTRACT:
SUBMITTER: Nair V
PROVIDER: S-EPMC5491285 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nair Viji V Robinson-Cohen Cassianne C Smith Michelle R MR Bellovich Keith A KA Bhat Zeenat Yousuf ZY Bobadilla Maria M Brosius Frank F de Boer Ian H IH Essioux Laurent L Formentini Ivan I Gadegbeku Crystal A CA Gipson Debbie D Hawkins Jennifer J Himmelfarb Jonathan J Kestenbaum Bryan B Kretzler Matthias M Magnone Maria Chiara MC Perumal Kalyani K Steigerwalt Susan S Ju Wenjun W Bansal Nisha N
Journal of the American Society of Nephrology : JASN 20170203 7
Growth differentiation factor-15 (GDF-15) is a member of the TGF-<i>β</i> cytokine superfamily that is widely expressed and may be induced in response to tissue injury. Elevations in GDF-15 may identify a novel pathway involved in loss of kidney function among patients with CKD. Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expression of <i>GDF15</i> mRNA correlates with circulating levels o ...[more]