Ontology highlight
ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC5491287 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fan Ying Y Xiao Wenzhen W Lee Kyung K Salem Fadi F Wen Jiejun J He Li L Zhang Jing J Fei Yang Y Cheng Dongsheng D Bao Hongda H Liu Yumei Y Lin Fujun F Jiang Gengru G Guo Zhiyong Z Wang Niansong N He John Cijiang JC
Journal of the American Society of Nephrology : JASN 20170130 7
Several animal studies have shown an important role for endoplasmic reticulum (ER) stress in AKI, whereas human studies are lacking. We recently reported that Reticulon-1A (RTN1A) is a key mediator of ER stress and kidney cell injury. Here, we investigated whether modulation of RTN1A expression during AKI contributes to the progression to CKD. In a retrospective study of 51 patients with AKI, increased expression of RTN1A and other ER stress markers were associated with the severity of kidney in ...[more]