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Exhaustive Suzuki-Miyaura reactions of polyhalogenated heteroarenes with alkyl boronic pinacol esters.

ABSTRACT: A novel Suzuki-Miyaura protocol is described that enables the exhaustive alkylation of polychlorinated pyridines. This method facilitates a formal synthesis of normuscopyridine and the rapid assembly of a dumbbell shaped portion of a [2]rotaxane.

SUBMITTER: Laulhe S

PROVIDER: S-EPMC5491353 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Exhaustive Suzuki-Miyaura reactions of polyhalogenated heteroarenes with alkyl boronic pinacol esters.

Laulhé Sébastien S Blackburn J Miles JM Roizen Jennifer L JL

Chemical communications (Cambridge, England) 20170601 53

A novel Suzuki-Miyaura protocol is described that enables the exhaustive alkylation of polychlorinated pyridines. This method facilitates a formal synthesis of normuscopyridine and the rapid assembly of a dumbbell shaped portion of a [2]rotaxane. ...[more]

PMID: 28345090

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