Ontology highlight
ABSTRACT:
SUBMITTER: Fransen F
PROVIDER: S-EPMC5491612 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Fransen Floris F van Beek Adriaan A AA Borghuis Theo T Meijer Ben B Hugenholtz Floor F van der Gaast-de Jongh Christa C Savelkoul Huub F HF de Jonge Marien I MI Faas Marijke M MM Boekschoten Mark V MV Smidt Hauke H El Aidy Sahar S de Vos Paul P
Frontiers in immunology 20170630
Males and females are known to have gender-specific differences in their immune system and gut microbiota composition. Whether these differences in gut microbiota composition are a cause or consequence of differences in the immune system is not known. To investigate this issue, gut microbiota from conventional males or females was transferred to germ-free (GF) animals of the same or opposing gender. We demonstrate that microbiota-independent gender differences in immunity are already present in ...[more]