Ontology highlight
ABSTRACT:
SUBMITTER: Verrier B
PROVIDER: S-EPMC5491952 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in immunology 20170630
Anti-p17 antibodies are able to neutralize human immunodeficiency virus (HIV) entry in a mouse model. In this study, we identified a region of sequence similarity between the epitopes of anti-p17 neutralizing antibodies and anti-gp41 neutralizing 2F5 antibody and verified cross-reactivity between p17 and 2F5 <i>in vitro</i>. The p17 sequence was modified to increase sequence identity between the p17 and 2F5 epitopes, which resulted in enhanced cross-reactivity <i>in vitro</i>. Immunogenicity of ...[more]