Ontology highlight
ABSTRACT:
SUBMITTER: McDonald MM
PROVIDER: S-EPMC5492093 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
McDonald Michelle M MM Reagan Michaela R MR Youlten Scott E SE Mohanty Sindhu T ST Seckinger Anja A Terry Rachael L RL Pettitt Jessica A JA Simic Marija K MK Cheng Tegan L TL Morse Alyson A Le Lawrence M T LMT Abi-Hanna David D Kramer Ina I Falank Carolyne C Fairfield Heather H Ghobrial Irene M IM Baldock Paul A PA Little David G DG Kneissel Michaela M Vanderkerken Karin K Bassett J H Duncan JHD Williams Graham R GR Oyajobi Babatunde O BO Hose Dirk D Phan Tri G TG Croucher Peter I PI
Blood 20170517 26
Multiple myeloma (MM) is a plasma cell cancer that develops in the skeleton causing profound bone destruction and fractures. The bone disease is mediated by increased osteoclastic bone resorption and suppressed bone formation. Bisphosphonates used for treatment inhibit bone resorption and prevent bone loss but fail to influence bone formation and do not replace lost bone, so patients continue to fracture. Stimulating bone formation to increase bone mass and fracture resistance is a priority; how ...[more]