Ontology highlight
ABSTRACT:
SUBMITTER: Sayou C
PROVIDER: S-EPMC5492175 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Sayou Camille C Millán-Zambrano Gonzalo G Santos-Rosa Helena H Petfalski Elisabeth E Robson Samuel S Houseley Jonathan J Kouzarides Tony T Tollervey David D
Molecular and cellular biology 20170629 14
Histone methylation at H3K4 and H3K36 is commonly associated with genes actively transcribed by RNA polymerase II (RNAPII) and is catalyzed by <i>Saccharomyces cerevisiae</i> Set1 and Set2, respectively. Here we report that both methyltransferases can be UV cross-linked to RNA <i>in vivo</i> High-throughput sequencing of the bound RNAs revealed strong Set1 enrichment near the transcription start site, whereas Set2 was distributed along pre-mRNAs. A subset of transcripts showed notably high enric ...[more]