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A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions.

ABSTRACT: Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.

SUBMITTER: Le CC

PROVIDER: S-EPMC5492256 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions.

Le Chi Chip CC Wismer Michael K MK Shi Zhi-Cai ZC Zhang Rui R Conway Donald V DV Li Guoqing G Vachal Petr P Davies Ian W IW MacMillan David W C DWC

ACS central science 20170517 6

Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic ...[more]

PMID: 28691077

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