Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC5492417 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Huang Yuran Y Li Yiwen Y Hu Ziying Z Yue Xiujun X Proetto Maria T MT Jones Ying Y Gianneschi Nathan C NC
ACS central science 20170518 6
A primary role of melanin in skin is the prevention of UV-induced nuclear DNA damage to human skin cells, where it serves to screen out harmful UV radiation. Melanin is delivered to keratinocytes in the skin after being excreted as melanosomes from melanocytes. Defects in melanin production in humans can cause diseases, many of which currently lack effective treatments due to their genetic origins (e.g., skin cancer, vitiligo, and albinism). The widespread prevalence of melanin-related diseases ...[more]