Ontology highlight
ABSTRACT:
SUBMITTER: Nichols DP
PROVIDER: S-EPMC5492972 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nichols Dave P DP Happoldt Carrie L CL Bratcher Preston E PE Caceres Silvia M SM Chmiel James F JF Malcolm Kenneth C KC Saavedra Milene T MT Saiman Lisa L Taylor-Cousar Jennifer L JL Nick Jerry A JA
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20161224 3
<h4>Background</h4>Concomitant use of oral azithromycin and inhaled tobramycin occurs in approximately half of US cystic fibrosis (CF) patients. Recent data suggest that this combination may be antagonistic.<h4>Methods</h4>Test the hypothesis that azithromycin reduces the clinical benefits of tobramycin by analyses of clinical trial data, in vitro modeling of P. aeruginosa antibiotic killing, and regulation of the MexXY efflux pump.<h4>Results</h4>Ongoing administration of azithromycin associate ...[more]