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The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

ABSTRACT: The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and we use the new insights to illuminate a few perplexing observations.

SUBMITTER: Kovall RA

PROVIDER: S-EPMC5492985 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

Kovall Rhett A RA Gebelein Brian B Sprinzak David D Kopan Raphael R

Developmental cell 20170501 3

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are trigger ...[more]

PMID: 28486129

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