Ontology highlight
ABSTRACT:
SUBMITTER: Eren RO
PROVIDER: S-EPMC5493041 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Eren Remzi Onur RO Reverte Marta M Rossi Matteo M Hartley Mary-Anne MA Castiglioni Patrik P Prevel Florence F Martin Ricardo R Desponds Chantal C Lye Lon-Fye LF Drexler Stefan K SK Reith Walter W Beverley Stephen M SM Ronet Catherine C Fasel Nicolas N
Cell host & microbe 20160901 3
Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti-viral innate immune responses affect parasitic infection are largely unknown. Upon investigating the mammalian host's response to LRV1, we found that miR-155 was singularly and strongly upregulated in macrophages infected with LRV1+ L.g when compar ...[more]